CRP and renal cell carcinoma: Based on this knowledge, systemic inflammatory markers such as neutrophils, lymphocytes, platelets, albumin, C-reactive protein (CRP) and biomarker combination ratios (e.g., neutrophil to lymphocyte ratio [NLR], LMR and platelet to lymphocyte ratio [PLR]) may have potential value in predicting pT3a upstaging in cT1 RCC patients.