It has been shown by the Cancer Genome Atlas (TCGA) and other studies that the ABL kinase (Abelson murine leukemia viral oncogene homolog 1) is amplified and/or overexpressed in various invasive solid tumors including breast, lung, colon, and kidney carcinoma as well as melanoma (1–3), though the role of ABL in oncogenic activity remains to be determined. The gene discussed is ABL1; the disease is renal carcinoma.