We used an FKBP chimeric form of ABL for which activity is enhanced by the small molecule FK1012 (17) and we observed that FKBP-ABL but not Mock or FKBP potentiated the expression of RUNX2 in a human osteosarcoma cell line, Saos-2 (Figure 4A). This evidence concerns the gene RUNX2 and osteosarcoma.