Although much progress has since been made in understanding how the RB-E2F pathway is involved in the pathogenesis of GC, the specific role of E2F family members and the RB-E2F pathway in GC has not been systematically reviewed since a review article on the role of E2Fs in cancers of digestive system was published in 2013 (13). The gene discussed is RB1; the disease is gastric cancer.