BRAF and melanoma: In patients with unresectable or metastatic BRAF-mutated (V600E or V600K) melanoma, the combination of BRAFi and MEK inhibitors (MEKi) is the current standard of care in the first-line setting, with three approved combinations: dabrafenib and trametinib, vemurafenib and cobimetinib, and encorafenib and binimetinib.