In parallel, immunohistochemistry (IHC) staining with tumor cell proliferation marker Ki67 in Patients 291,292 and 284 pre- and 1 month post- SNCP-125I brachytherapy showed that tumor proliferation was significantly suppressed after SNCP-125I brachytherapy (p=0.012, Figures 10A, B and Supplemental Figure 7A). Here, MKI67 is linked to neoplasm.