PKM and melanoma: Previous proteomic analysis has identified that many glycolytic enzymes, including such as glyceraldehyde-3-phosphate dehydrogenase (GAPDH), ENO1, muscle pyruvate kinase (PKM2), phosphoglycerate mutase 1 (PGK1), lactate dehydrogenase (LDH), isocitrate dehydrogenases 1 (IDH1), glucose 6 phosphate dehydrogenase (G6PD), and aldehyde dehydrogenase (ALDH), are enriched in the invadopodia lysate of human melanoma cells (52).