The functional importance of sENO1 in tumor progression was further validated by the ability of a function-inhibiting anti-ENO1 antibody, which suppresses cell-associated plasminogen activation and matrix metalloproteinase activation and thereby inhibits matrix degradation and cell invasion, to inhibit tumor metastasis in various animal models of lung cancer and PDAC (38, 40). This evidence concerns the gene PLG and lung carcinoma.