The functional importance of sENO1 in tumor progression was further validated by the ability of a function-inhibiting anti-ENO1 antibody, which suppresses cell-associated plasminogen activation and matrix metalloproteinase activation and thereby inhibits matrix degradation and cell invasion, to inhibit tumor metastasis in various animal models of lung cancer and PDAC (38, 40). The gene discussed is ENO1; the disease is lung cancer.