In keeping with this notion, Stankic et al. reported that the inhibitor of DNA binding 1 (ID1)-dependent transcriptional repression of TWIST1 converts metastatic breast cancer cells from an EMT to a mesenchymal-epithelial transition state, and this phenotypic conversion is required for their metastatic colonization in the lung (57). This evidence concerns the gene TWIST1 and breast carcinoma.