Complementing these observations, suppressing invadopodia by inhibiting Src, twist family BHLH transcription factor 1 (TWIST1), platelet-derived growth factor receptor alpha (PDGFR-α), TKS5 or a specific variant of ENAH actin regulator (MENA; MENAINV), has been shown to inhibit tumor metastasis in various tumor models (26). Here, ENAH is linked to neoplasm.