The mean ALT and AST levels were higher in co-infection with dengue viruses as compared to infection with a single serotype (Table 6), and they were significantly higher in serotypes-2, 3, and 4 as compared to serotype-1 (Table 4), indicating the possibility of a greater hepatotropic nature of serotypes-2, 3, and 4. This evidence concerns the gene GPT and coinfection.