Compared with the saline treatment model group, propofol significantly increased the ACh levels and ChAT activities (p < .01, respectively, Figure 2a,b) while also decreasing the AChE activities (p < .01, respectively, Figure 2c) in brain tissues of BCCAO rats after treatment, indicating that propofol can effectively repair CCH‐induced central cholinergic dysfunction. The gene discussed is ACHE; the disease is columnar cell hyperplasia of the breast.