In another study, Lu et al. [46] showed that MATN3 promoted the synthesis of COL2 and ACAN by promoting IL-1ra expression and inhibited the production of IL-1β-induced catabolic matrix proteinases, thereby delaying intervertebral disc degeneration by reducing extracellular matrix degradation. The gene discussed is IL1B; the disease is Intervertebral disk degeneration.