The concentrations of CT were found to be significantly different in early RA patients as compared with the SLE, GA, and healthy groups (p < 0.0001), and upon further investigation, it was determined that this difference in expression resided mostly between healthy individuals and patients with early RA: median serum CT concentrations were significantly lower (p < 0.0001) in patients with early RA (0.880 pg/ml) compared with healthy controls (3.159 pg/ml) as presented in Figure 1(b). The gene discussed is CALCA; the disease is rheumatoid arthritis.