IL6 and rheumatoid arthritis: Soluble inflammatory mediators of systemic inflammation such as C-reactive protein (CRP), interleukin-6 (IL-6), tumor necrosis factor (TNF-α), and anti-inflammatory marker IL-10 are highly expressed in synovium fluid and serum of arthritic patients, which play a critical role in the pathophysiology of RA [10, 11].