In the study of renal disease, it was found that RhoA/ROCK1 is the upstream signal molecule of NOX4/ROS, and the activation of the RhoA/ROCK1 signal pathway can upregulate the expression of NOX4/ROS, promote the differentiation of renal myofibroblasts, and aggravate renal fibrosis [34]. This evidence concerns the gene ROCK1 and renal fibrosis.