Animal experiments have shown that in a mouse model of T2DM, the specific identity transcription factors Nkx6.1 and Pdx1 of pancreatic β-cells decrease, while the progenitor cell markers Neurogenin 3 (Ngn3) and OCT4 increase, affecting the function and number of pancreatic β-cells [73]. The gene discussed is NEUROG3; the disease is type 2 diabetes mellitus.