And the differential expression of PIK3CA induced by Beroukhim 3q gain was speculated to take part in the tumorigenesis of lung adenocarcinoma when TP53 silencing (Yang et al., 2014; Hou et al., 2020; Wang F. et al., 2020; Figure 4C and Supplementary Table 6_TP53_weight). This evidence concerns the gene TP53 and lung adenocarcinoma.