However, this gene is associated with several hyperacetylated and hypomethylated distal enhancers, one of which is located at 330 kilobases (kb) upstream of the PAX5 TSS, and has been also found as extensively mutated in CLL (Puente et al., 2015) (Figure 6). The gene discussed is PAX5; the disease is B-cell chronic lymphocytic leukemia.