The pathways referenced from the KEGG database showed that the DEGs highly expressed in the high-risk group were mainly involved in acute myeloid leukemia while the DEGs down-regulated in the low-risk group were markedly involved in signaling pathways for IL-17, viral protein interactions with cytokine and cytokine receptor, NF-kappa B signaling, and the TNF signaling pathway (Figure 5D). The gene discussed is TNF; the disease is acute myeloid leukemia.