To identify potential key enzymes related to Lewis antigens in miscarriage, we evaluated the expression patterns of three α-2,3 sialyltransferases, ST3GAL3, -4, and -6, which act on the N-Acetyllactosamine structure (Galβ1,3/4GlcNAc) to create sLeA/X and related sialofucosylated glycans. Here, ST3GAL3 is linked to Miscarriage.