Lastly, a review of genes mapping to components of bacterial and parasite pathways including the Ap-1 and PI3K-Akt signaling pathway (hsa04151) in Salmonella infection (sasa05132), and the human Entamoeba histolytica amoebiasis pathway (hsa05146), provided insight to the proposed host-parasite model for AGD. This evidence concerns the gene AKT1 and amebiasis.