Most genes involved in the complement cascade were over-expressed in TUBE early and INFL compared to HTLY (Supplementary Figure 14 right panel) but their expression was usually lower among COVID-19 compared to INFL (“ascending” pattern, e.g. C1QC, C2, C5), with the exception of C3, that, was over-expressed in TUBE early compared to INFL patients (Figure 10 and Supplementary Figure 14 left panel). Here, C3 is linked to COVID-19.