Most striking was the under-expression of genes involved in viral recognition (e.g. TLR7, UNC93B, RIG-I/DDX58, Figure 3), as well as genes encoding downstream signaling molecules and transcription factors (e.g. TRIF/TICAM1, MYD88, IRF7, Figure 3), with the notable exception of IRF4, in COVID-19 compared to INFL (Figure 4). The gene discussed is IRF4; the disease is COVID-19.