In contrast, genes involved in antigen presentation through MHC II presented a “valley” pattern, with under-expression among TUBE early compared to HLTY and COVID-19 compared to INFL, which strikingly predominated in TUBE early (e.g. HLA-DRA, HLA-DRB1, HLA-DQA1, CD74/Ii/CLIP/SLIP, Figure 7). Here, HLA-DRB1 is linked to COVID-19.