Specifically, riboflavin supplementation resulted in a reduction in proinflammatory factors (TNF-α, IL-6, MCP-1, HMGB1) and an increase in anti-inflammatory factors adiponectin and IL-10 (38), highlighting the need for further evaluation of this micronutrient as a promising target in the treatment of inflammatory conditions associated with obesity and metabolic syndrome. The gene discussed is IL6; the disease is metabolic syndrome.