Protection from acute respiratory infections.↓Severity of COVID-19.↓Anti-Tg antibodies in Hashimoto’s thyroiditis.Anti-inflammatory activity (↓TNF-α, IFN-γ, IL12p70) in ulcerative colitis.Decrease in markers of T cell activation/exhaustion and monocyte activation in HIV infection.Immunoregulation in type 1 diabetes. The gene discussed is IFNG; the disease is COVID-19.