Furthermore, although several baseline characteristics (larger uterine volume and higher proportion of associated endometriomas) of women with adenomyosis undergoing the ultra-long GnRH-a protocol were worse, the early miscarriage rate in women undergoing the ultra-long GnRH-a protocol was significantly lower than those undergoing the long GnRH-a protocol, which implied that the ultra-long GnRH-a protocol had more advantages than the long GnRH-a protocol in women with adenomyosis. The gene discussed is GNRH1; the disease is adenomyosis.