Moreover, the Upstream Regulator Analysis by IPA tool revealed that the expression of 11 genes associated with AMD (APOE, ATF6, CYP24A1, INNP5D, IL2RA, IL6, IL23R, MAPK1, MIF, MIRNA196A, and TNFSF14) may be affected by a regulatory network including APP, CREBBP, IFNG, PSEN1, TGFB1, and VEGFA genes (Figure 3). This evidence concerns the gene ATF6 and age-related macular degeneration.