Chronic kidney disease is associated with an imbalance of vasoactive substances in the kidney, with an increase in vasoconstrictor agents, such as Ang II and endothelin-1, and a reduction in vasodilator agents, such as nitric oxide, bradykinin, and ANP, which causes renal hemodynamics alterations and intraglomerular capillary hypertension (Benigni et al., 2004). Here, AGT is linked to chronic kidney disease.