NPPA and hypertensive disorder: Several facts reveal the importance of corin or PCSK6 in the metabolic pathway of ANP and its effects on sodium homeostasis and blood pressure: (1) mutations in corin gene that affect its activation are associated with hypertension and preeclampsia (Cui et al., 2012; Dong et al., 2013), (2) in CKD patients, as well as proteinuric rats, it has been described reduced levels of corin in the kidney (Polzin et al., 2010; Fang et al., 2013), and (3) PCSK6 KO mice develop salt-sensitive hypertension and exhibit undetectable levels of corin and pro-auricular ANP activity (Chen et al., 2015).