The aims of this study are (i) to analyze the level of miR-223 in platelets, plasma samples and isolated PMPs from septic patients in comparison to control individuals, (ii) to observe the internalization of sepsis PMPs into endothelial cells, involving the transfer of miR-223, and (iii) to investigate the effects of PMPs containing miR-223 on ICAM-1 expression and leukocyte adhesion on endothelial cell cultures in the septic milieu. The gene discussed is ICAM1; the disease is Sepsis.