Mechanistically, we further revealed in vitro that the inhibitory effects of sacubitril/valsartan on myocardial fibroblast proliferation and collagen synthesis through downregulation of TGF-β1/Smads signaling may be casually related to its better cardioprotective effects.Ventricular remodeling post-MI is known to be associated with the progression of heart failure and poor long-term prognosis. This evidence concerns the gene TGFB1 and heart failure.