Therefore, we aimed to investigate whether sacubitril/valsartan can improve cardiac remodeling and function in rats after myocardial infarction, and inhibit TGF-β1-induced myocardial fibroblast proliferation and collagen synthesis, and verify whether these effects are related to its inhibition of TGF-β1/Smads signaling pathway activation. The gene discussed is TGFB1; the disease is myocardial infarction.