Our results have been further confirmed by a recent study by Zhang W et al., who found in rats with heart failure with preserved ejection fraction induced by high-salt diet that, sacubitril/valsartan effectively alleviated the symptoms probably by inhibiting fibrosis via the TGF-β1/Smad3 signaling pathway (Zhang et al., 2020). Here, TGFB1 is linked to heart failure.