In addition to miRNAs, noncoding RNAs, such as long non-coding RNAs (lncRNAs) and circular RNAs (circRNAs), have also attracted extensive attention due to their important regulatory roles in tumor development involving in Wnt/β-catenin, PI3K/AKT/mTOR, Notch and NF-KB pathways (Anastasiadou et al., 2018). This evidence concerns the gene PIK3CA and neoplasm.