Exposure of NSCLC cells to epidermal growth factors or hypoxia causes the activation of hypoxia inducible factor-1 (HIF-1), which ultimately leads to the significant upregulation of C-X-C motif chemokine receptor 4 (CXCR4) expressions and chemotactic behavior. The gene discussed is CXCR4; the disease is non-small cell lung carcinoma.