In this study, it was confirmed that the anti-inflammatory Choline acetyltransferase (ChAT)+ T cells in the intestinal mucosa and Peyer’s patches (PP) are increased by the activation of β2AR receptors, thereby improving the integrity of the intestinal mucosal barrier and symptoms of colitis (see Table 1) (Willemze et al., 2019a). Here, CHAT is linked to colitis.