In addition, amyloid β deposition and overexpression of phosphorylated Tau protein in intestinal myenteric neurons of neurodegenerative disorder Alzheimer’s disease (AD) mice, significantly increased the number of CD68+ macrophages in the ileum and further led to the loss of intramuscular nitrogenous and cholinergic neurons in the ENS (see Table 4) (Han et al., 2017). Here, CD68 is linked to Alzheimer disease.