MAPT and Alzheimer disease: In addition, amyloid β deposition and overexpression of phosphorylated Tau protein in intestinal myenteric neurons of neurodegenerative disorder Alzheimer’s disease (AD) mice, significantly increased the number of CD68+ macrophages in the ileum and further led to the loss of intramuscular nitrogenous and cholinergic neurons in the ENS (see Table 4) (Han et al., 2017).