Investigating NaV1.1 channel dysfunction, which are expressed also in central neurons (Ogiwara et al., 2007; Favero et al., 2018; Sakkaki et al., 2020), in relation to changes in neuronal excitability, is also of relevance to various neurological disorders other than migraine, foremost childhood epilepsy (Menezes et al., 2020), autism spectrum disorder (Scheffer and Nabbout, 2019), Alzheimer’s disease (Sakkaki et al., 2020), and perhaps less known, transient cerebral ischemia (Zhan et al., 2007). This evidence concerns the gene SCN1A and nervous system disorder.