Moreover, the observation that mutated NaV1.1 channels can facilitate spontaneous CSD events may also have relevance to, for instance, stroke as relative peri-infarct depolarizations (PID) known to circle around the infarct core (Sukhotinsky et al., 2010), when occurring more easily, may lead to an increase in the infarct size and worse stroke outcome. This evidence concerns the gene SCN1A and Stroke.