MBTPS1 and myeloid sarcoma: The bioactive S1P selectively binds to high affinity cell surface G protein-coupled receptors (GPCRs; S1PRs), named S1P1, S1P2, S1P3, S1P4, and S1P5 (Ishii et al., 2004) that have been involved in the majority of physiological and pathological actions evoked by S1P such as immune response, cardiovascular functions, cancer, atherosclerosis (Cartier and Hla, 2019) as well as MS (Strub et al., 2010; Maceyka et al., 2012).