Finally, it was reported that both pharmacological inhibition/knockdown of SphK2, and overexpression of S1P lyase/SPP1 in neuroblastoma cells abrogate BACE1-mediated Aβ production (Takasugi et al., 2011) whereas exogenous S1P failed to increase amyloid-beta (Aβ) production. This evidence concerns the gene SPHK2 and neuroblastoma.