In particular, both higher CRP and IL-6 showed converging associations with hypersomnia (CRP OR = 1.27, 95% CI = 1.13–1.43; IL-6 OR = 1.26, 95% CI = 1.07–1.49) and fatigue (CRP OR = 1.12, 95% CI = 1.04–1.21; IL-6 OR = 1.19, 95% CI = 1.07–1.33). This evidence concerns the gene IL6 and hypersomnia.