These results align with an extensive evidence-base suggesting an association between inflammation and depression, and with a more limited evidence-base indicating an association between increased CRP levels mainly in subjects with generalised anxiety disorder (GAD), including our previous work from NESDA, ALSPAC, and UK Biobank cohorts [2–5, 9, 11, 17–19, 21, 34–36]. This evidence concerns the gene CRP and major depressive disorder.