Insulin-like growth factor 1 (IGF-1)/IGF-1 receptor (IGF-1R) autocrine signalling and the subsequent AKT activation was identified as a common mechanism to promote dormancy in KRAS- and c-MYC null-pancreatic cancer cells; and pancreatic dormant cells were eliminated when treated with IGF-1R inhibitor116. The gene discussed is IGF1R; the disease is pancreatic neoplasm.