In IS-high samples, increased expression of PD-L1 (27.9% in IS-low vs. 48.2% in IS-high; p = 0.0336), HLA-E (73.8% vs. 90.7%; p = 0.0282) and PVR (70.5% vs. 87.0%; p = 0.0415) on tumor cells was detected (Fig. 5b). This evidence concerns the gene CD274 and neoplasm.