Thirdly, stable right and left ventricular function as well as stable laboratory and imaging biomarkers such as NT-proBNP, hs-TnT, and myocardial native T1 time do not indicate that these cardiac adaptions caused severe myocardial injury with impairment of systolic function in patients with normal LV function, no relevant heart valve defects, and a maximum diastolic dysfunction of grade 2. The gene discussed is NPPB; the disease is medical procedure.