We included LIN28B and TP53 as test subjects because LIN28B is enriched in iCluster-3 along with CTAs (Fig. 1a) and is a major miRNA binding protein that intersects with mutant p53 signaling in cancer progression16, whereas p53 is a major mutated gene in HCC iCluster-315. The gene discussed is TP53; the disease is hepatocellular carcinoma.