CASP1 and Alzheimer disease: CASP1 mRNA levels were significantly up-regulated in AD TCX (Fig. 1h) and STG (Fig. 1i), but not in PHG (Fig. 1j), DLPFC (Fig. 1k), CER (Fig. 1l), FP (Fig. 1m), or IFG (Fig. 1n), compared to cognitively normal older adults.