Casp6 can cleave numerous protein substrates, some of which are specific to neurons and synapses2,59 and involved in neurodegenerative diseases, such as Tau, Vimentin, Drebrin, Spinophilin, α-Actinin2,5, valosin containing protein p973, APP60, Presenilin 1 and 228, and Huntingtin61, that may be responsible for structural damage, synaptic loss, and protein aggregation. Here, VCP is linked to neurodegenerative disease.