CASP6 and Alzheimer disease: Gene expression association analysis using RNA-Seq data generated from temporal cortex (TCX), para-hippocampal gyrus (PHG), inferior frontal gyrus (IFG), superior temporal gyrus (STG), frontal pole (FP), dorsolateral prefrontal cortex (DLPFC), and cerebellum (CER) identified that CASP6 mRNA was up-regulated in the TCX (Fig. 1a), STG (Fig. 1b), PHG (Fig. 1c), and DLPFC (Fig. 1d) of AD compared to cognitively normal older adults.