Variants were found in genes associated with hypertrophic cardiomyopathy (MYBPC3, MYH7, TNNI3, TNNT2, GLA, N = 24 carriers), dilated cardiomyopathy (TTN, LMNA, PLN, BAG3, N = 29 carriers), arrhythmogenic right-ventricular cardiomyopathy (PKP2, DSP, DSC2, N = 22 carriers), catecholaminergic polymorphic ventricular tachycardia (RYR2, N = 4 carriers), Marfan syndrome and familial thoracic aortic aneurysms and dissections (FBN1, N = 1 carrier), and familial long-QT syndrome types 1,2, and 3 (KCNQ1, KCNH2, SCN5A, N = 39 carriers). Here, TTN is linked to familial thoracic aortic aneurysm and aortic dissection.