Variants in genes associated with arrhythmogenic right-ventricular cardiomyopathy (PKP2, DSP, DSC2, DSG2, TMEM43) were found in 22/13,131 ASPREE participants, at a prevalence of 0.17%, also lower than rates reported in population-based studies (0.23%)9. The gene discussed is TMEM43; the disease is Arrhythmogenic right ventricular dysplasia.