We used confocal microscopy to investigate the effects of equivalent infectious doses of HRV-16 (uses ICAM-1 receptor), HRV-1A (uses LDL receptor), and HRV-C15 (uses CDHR3 receptor) on tight junction organization (ZO-1 and occludin) at 24 h post infection in highly differentiated ALI cultures (Fig. 1a). The gene discussed is LDLR; the disease is infection.