Thus, while both oligomycin A and 2-DG can suppress viral titers, differential effects on epithelial function suggest that the regulation of oxidative phosphorylation and PGC-1α expression is a more rational target for therapeutic intervention that could be particularly beneficial in children with asthma or cystic fibrosis during HRV-C infections. The gene discussed is PPARGC1A; the disease is cystic fibrosis.