GPT and Hepatitis: In addition, and as previously reported8,9, the marker of hepatocellular damage ALT (Fig. 8b) as well as several other markers of liver damage detected by anatomopathological analysis (necrosis, fibrosis, and hepatitis) (Supplementary Fig. 8b, bottom) were increased in Li-TSC1−/− mice and mainly absent in Li-RagAGTP/Δ mice.