TSC1 and tuberous sclerosis: All weaned RagAGTP/∆ mice exhibited a fully-penetrant hypopigmented coat (Fig. 1d), a phenotype also observed in tuberous sclerosis patients and in other syndromes related with increased mTORC1 activity23, and also in TSC1 floxed strain bred to a strain of transgenic mice that express the Cre recombinase in a melanocyte-specific promoter7.