Chromosomal translocations involving transcription factors are frequently seen in acute leukemia, and some of them have been used as genetic markers for leukemia classification because of their distinctive clinicopathological features and prognostic significance, such as AML with RUNX1-RUNX1T1 and B-ALL with TCF3-PBX1. The gene discussed is RUNX1; the disease is acute lymphoblastic leukemia.