Chromosomal translocations involving transcription factors are frequently seen in acute leukemia, and some of them have been used as genetic markers for leukemia classification because of their distinctive clinicopathological features and prognostic significance, such as AML with RUNX1-RUNX1T1 and B-ALL with TCF3-PBX1. This evidence concerns the gene TCF3 and acute myeloid leukemia.