Among them, RUNX1-RUNX1T1, NUP98-NSD1, KMT2A-MLLT3, and DEK-NUP214 were more frequent in pediatric AML, while PML-RARA and CBFB-MYH11 were more common in adult AML (Table S2). Here, RUNX1 is linked to acute myeloid leukemia.