As shown in Figure 1A, PXN expression in human tumors of cholangiocarcinoma, esophageal carcinoma, glioblastoma multiforme (GBM), head and neck squamous cell carcinoma (HNSC), liver hepatocellular carcinoma (LIHC), thyroid carcinoma (P < 0.001), prostate adenocarcinoma (PRAD), stomach adenocarcinoma (P < 0.01), and kidney chromophobe (P < 0.05) were higher than expressions in paired normal tissues. This evidence concerns the gene PXN and head and neck squamous cell carcinoma.