However, PXN expression in breast invasive carcinoma (BRCA), colon adenocarcinoma (COAD), kidney renal papillary cell carcinoma, lung adenocarcinoma (LUAD), lung squamous cell carcinoma (LUSC), uterine corpus endometrial carcinoma (UCEC) (P < 0.001), and pheochromocytoma and paraganglioma (P < 0.05) were significantly downregulated. This evidence concerns the gene PXN and squamous cell lung carcinoma.