To evaluate the link between impairment of functional outcome with dysregulation in the neurotransmitter signaling pathways (Geyer et al., 2001; Wurm et al., 2007; Aan Het Rot et al., 2009; Mickey et al., 2011; Hamon and Blier, 2013), we next demonstrated the role of ICAM-1 in regulating neurotransmitters expression and thereby control sensorimotor function, and depression and anxiety-like psychological stress behaviors. This evidence concerns the gene ICAM1 and depressive disorder.