Upon activation and strong adherence, the leukocytes flatten and soon undergo diapedesis to enter the parenchyma of the brain that advocates LFA-1/ICAM-1 interaction phenomena as a therapeutic target against various pathophysiology conditions of neurologic disorders, and cancer (Rancan et al., 2001; Hamaï et al., 2008). This evidence concerns the gene ICAM1 and nervous system disorder.