In the light-dark box test, ICAM-1 deletion monitored at 48 h and 14 d postinjury in both 10 and 20 psi injury group causes a significant increase in latency to stay in the light chamber or number of transition when compared with WT 10 and 20 psi injured mice (F(15,48) = 10.25, p < 0.0001; Fig. 7E), indicating that ICAM-1 is partly involved in regulating depression and anxiety-like psychological stress behavior. Here, ICAM1 is linked to major depressive disorder.