CDH8 and autism: In line with the expression profile in the NPCs, autism-specific iPSC-derived cortical organoids showed a significant increase of CDH8 (control: 1.072 ± 0.1783, autism: 3.093 ± 0.6812; Fig. 5C) and a concomitant decrease of CDH11 (control: 1.016 ± 0.0249, autism: 0.5603 ± 0.0517; Fig. 5D) compared with neurotypical control organoids.