SLE patients no matter with or without LN had higher IgA anti-HRGEC antibody serum levels than healthy controls (1.39 ± 0.40 vs 0.43 ± 0.17, p < 0.001; 1.25 ± 0.28 vs 0.43 ± 0.17, p < 0.001). The gene discussed is CD79A; the disease is systemic lupus erythematosus.