VIM and neoplasm: Under the regulation of EMT related transcription factors Snai, Twist, Zeb and E47 [13, 14], the expression of epithelial cell specific proteins, such as epithelial cell adhesion molecule (EpCAM), E-cadherin and cytokeratin [15, 16], were down regulated in tumor cells located in the original site, while mesenchymal specific proteins such as N-cadherin and vimentin were overexpressed.