The highest quartile of VWF as compared with lower levels of VWF was associated with a 1.4-fold (95 %CI 1.1–1.8) increased mortality risk after adjustment for age, sex, body mass index, cardiovascular disease, smoking, dialysis modality, primary kidney disease, use of antithrombotic medication, systolic blood pressure, albumin levels, CRP levels and residual GFR (Table 2). This evidence concerns the gene CRP and cardiovascular disorder.