Interestingly, three genes were differentially expressed in both neutrophil cell culture without RvE1 treatment and the baseline serum analysis, including NECTIN2, HTRA3, and ABCG1. Importantly, treatment of the T2D neutrophils in cell culture with a clinically relevant dose, 100 nM, of exogenous RvE1 was able to reduce both the overall number of genes differentially expressed relative to healthy neutrophils and the level of differential expression of NECTIN2 and ABCG1, suggesting a partial normalization of these neutrophils with RvE1 treatment. Here, HTRA3 is linked to type 2 diabetes mellitus.