After treatment with 10 nM or 100 nM RvE1, TNF-α levels were elevated in healthy neutrophils, reaching levels seen in T2D neutrophils; a similar effect was observed at 100 nM RvE1 for P-Selectin, though healthy levels (1511 pg/mL) did not fully rise to match T2D levels (1751 pg/mL). This evidence concerns the gene SELP and type 2 diabetes mellitus.