The KEGG pathways of Type II diabetes mellitus (enriched with MAPK10, PRKCE, GCK, MTOR, PIK3R1), cAMP signaling pathway (enriched with ADCY1, ACOX3, ADCY5, ARAP3, PIK3R1, MAPK10, GRIN2B, VIPR2, and VAV2), the GO terms of skeletal muscle acetylcholine-gated channel clustering (enriched with COLQ and DNAJA3) and the cAMP-mediated signaling (enriched with ADCY1, ADCY5, and KSR1) were identified in CHP vs. YP. The gene discussed is COLQ; the disease is type 2 diabetes mellitus.