MAPK3 and familial pancreatic carcinoma: Certain scholars have reported that UCA1 is highly expressed in the exosomes derived from hypoxic pancreatic cancer cells and could be transferred to human umbilical vein endothelial cells via these exosomes, which suggests that hypoxic exosomal UCA1 might promote angiogenesis and tumor growth through the miR-96–5p/AMOTL2/ERK1/2 axis (Guo et al. 2020).