ACE2 and Headache: In such a situation, the COVID-related cytokine storm could promote several mechanisms associated with headaches: 1, an atypical response of the mast cells (34); 2, a dramatic increase of interleukin-6 (IL-6) levels (35); 3, over-expression of the angiotensin-converting enzyme 2 (ACE2) at central and peripheral nervous systems (36).