SORL1 and Alzheimer disease: Therefore, SORL1 is potentially involved in the pathogenesis of both early- and late-onset AD (Bettens et al., 2008; Caglayan et al., 2012; Kimura et al., 2009; Nicolas et al., 2016; Rogaeva et al., 2007; Tan et al., 2009; Verheijen et al., 2016).