CUX2 and bipolar disorder: CUX2, on the other hand, is a hotspot for de novo missense mutations in NDDs (Geisheker et al., 2017), including ASD (Barington et al., 2018; Chatron et al., 2018; De Rubeis et al., 2014; Geisheker et al., 2017) and has also been associated with bipolar disorder (Glaser et al., 2005; Jacobsen et al., 2001).